Porting and tuning of the Mont-Blanc benchmarks to the multicore ARM 64bit architecture

This project is about porting and tuning the Mont-Blanc benchmarks to the multicore ARM 64 bits architecture. The Mont-Blanc benchmarks are part of the Mont-Blanc European project and they have been developed internally in the BSC (Barcelona Supercomputing Center). The project will explore the possibilities that an ARM architecture can offer running in a HPC (High Performance Computing) setup, this includes to learn how to tune and adapt a parallelized computer program and analyze its execution behavior. As part of the project, we will analyze the performance of each benchmark using instrumentation tools such like Extrae and Paraver. Each benchmark will be adapted, tuned and executed mainly in the three new Mont-Blanc mini-clusters, Thunder (ARMv8 custom), Merlin (ARMv8 custom) and Jetson TX (ARMv8 cortex-a57) using the OmpSs programming model. The evolution of the performance obtained will be shown followed by a brief analysis of the results after each optimization.Aquest projecte es basa en adaptar i afinar els Mont-Blanc benchmarks a l’arquitectura multinucli ARM 64 bits. Els Mont-Blanc benchmarks formen part del projecte Europeu Mont-Blanc i han estat desenvolupats internament en el BSC (Barcelona Supercomputing Center). Aquest projecte explorarà el potencial d’usar l’arquitectura ARM en un entorn HPC (High Performance Computing), això inclou aprendre a adaptar i afinar un programa paral·lel, i analitzar el seu comportament durant l’execució. Com a part del projecte, s’analitzarà el rendiment de cada benchmark usant eines d’instrumentació com Extrae o Paraver. Cada benchmark serà adaptat, afinat i executat en els tres nous miniclústers de Mont-Blanc, Thunder (ARMv8 personalitzat), Merlin (ARMv8 personalitzat) i Jetson TX (ARMv8 cortex-a57) usant el model de programació OmpSs. Es mostrarà l’evolució del rendiment, seguit d’una breu explicació dels resultats després de cada optimització.Este proyecto se basa en adaptar y afinar los Mont-blanc benchmarks a la arquitectura multi-núcleo ARM 64 bits. Los Mont-Blanc benchmarks forman parte del proyecto Europeo Mont-Blanc y han sido desarrollados internamente en el BSC (Barcelona Supercomputing Center). Este proyecto explorará el potencial de usar la arquitectura ARM en un entorno HPC (High Performance Computing), esto incluye aprender a adaptar y afinar un programa paralelo, y analizar su comportamiento durante la ejecución. Como parte del proyecto, se analizará el rendimiento de cada benchmark usando herramientas de instrumentación como Extrae o Paraver. Cada benchmark será adaptado, afinado y ejecutado en los tres nuevos mini-clústeres de Mont-Blanc, Thunder (ARMv8 personalizado), Merlin (ARMv8 personalizado) y Jetson TX (ARMv8 cortex-a57) usando el modelo de programación OmpSs. Se mostrará la evolución del rendimiento obtenido, y una breve explicación de los resultados después de cada optimización

An architectural journey into RISC architectures for HPC workloads

The thesis evaluates the current state-of-the-art of RISC architectures in HPC. Studying the performance, power, and energy to solution in heterogeneous SoCs. For the evaluation 2 arm platforms (CPU+GPU, CPU+FPGA), 1 RISC-V platform and 1 Open Source RISC-V core running in an FPGA have been tested

Is Arm software ecosystem ready for HPC?

In recent years, the HPC community has increasingly grown its interest towards the Arm architecture with research projects targeting primarily the installation of Arm-based clusters. State of the art research project examples are the European Mont-Blanc, the Japanese Post-K, and the UKs GW4/EPSRC. Primarily attention is usually given to hardware platforms, and the Arm HPC community is growing as the hardware is evolving towards HPC workloads via solutions borrowed from mobile market e.g., big.LITTLE and additions such as Armv8-A Scalable Vector Extension (SVE) technology. However the availability of a mature software ecosystem and the possibility of running large and complex HPC applications plays a key role in the consolidation process of a new technology, especially in a conservative market like HPC. For this reason in this poster we present a preliminary evaluation of the Arm system software ecosystem, limited here to the Arm HPC Compiler and the Arm Performance Libraries, together with a porting and testing of three fairly complex HPC code suites: QuantumESPRESSO, WRF and FEniCS. The selection of these codes has not been totally random: they have been in fact proposed as HPC challenges during the last two editions of the Student Cluster Competition at ISC where all the authors have been involved operating an Arm-based cluster and awarded with the Fan Favorite award.The research leading to these results has received funding from the European Community's Seventh Framework Programme [FP7/2007-2013] and Horizon 2020 under the Mont-Blanc projects [3], grant agreements n. 288777, 610402 and 671697. The authors would also like to thank E4 Computer Engineering for providing part of the hardware resources needed for the evaluation carried out in this poster as well as for greatly supporting the Student Cluster Competition team.Postprint (author's final draft

The ratio of CRP to prealbumin levels predict mortality in patients with hospital-acquired acute kidney injury

<p>Abstract</p> <p>Background</p> <p>Animal and human studies suggest that inflammation and malnutrition are common in acute kidney injury (AKI) patients. However, only a few studies reported CRP, a marker of inflammation, albumin, prealbumin and cholesterol, markers of nutritional status were associated with the prognosis of AKI patients. No study examined whether the combination of inflammatory and nutritional markers could predict the mortality of AKI patients.</p> <p>Methods</p> <p>155 patients with hospital-acquired AKI were recruited to this prospective cohort study according to RIFLE (Risk, Injury, Failure, Lost or End Stage Kidney) criteria. C-reactive protein (CRP), and the nutritional markers (albumin, prealbumin and cholesterol) measured at nephrology consultation were analyzed in relation to all cause mortality of these patients. In addition, CRP and prealbumin were also measured in healthy controls (n = 45), maintenance hemodialysis (n = 70) and peritoneal dialysis patients (n = 50) and then compared with AKI patients.</p> <p>Results</p> <p>Compared with healthy controls and end-stage renal disease patients on maintenance hemodialysis or peritoneal dialysis, patients with AKI had significantly higher levels of CRP/prealbumin (<it>p </it>< 0.001). Higher level of serum CRP and lower levels of albumin, prealbumin and cholesterol were found to be significant in the patients with AKI who died within 28 days than those who survived >28 days. Similarly, the combined factors including the ratio of CRP to albumin (CRP/albumin), CRP/prealbumin and CRP/cholesterol were also significantly higher in the former group (<it>p </it>< 0.001 for all). Multivariate analysis (Cox regression) revealed that CRP/prealbumin was independently associated with mortality after adjustment for age, gender, sepsis and sequential organ failure assessment (SOFA, <it>p </it>= 0.027) while the others (CRP, albumin, prealbumin, cholesterol, CRP/albumin and CRP/cholesterol) became non-significantly associated. The hazard ratio was 1.00 (reference), 1.85, 2.25 and 3.89 for CRP/prealbumin increasing according to quartiles (<it>p </it>= 0.01 for the trend).</p> <p>Conclusions</p> <p>Inflammation and malnutrition were common in patients with AKI. Higher level of the ratio of CRP to prealbumin was associated with mortality of AKI patients independent of the severity of illness and it may be a valuable addition to SOFA score to independent of the severity of illness and it may be a valuable addition to SOFA score to predict the prognosis of AKI patients.</p

Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility.

Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated. Makorin-2 (Mkrn2) is an evolutionarily conserved gene whose biological functions are not fully known. We developed an Mrkn2 knockout mouse model to study the role of this gene, and found that deletion of Mkrn2 in mice led to male infertility. Mkrn2 knockout mice produced abnormal sperms characterized by low number, poor motility, and aberrant morphology. Disruption of Mkrn2 also caused failure of sperm release (spermiation failure) and misarrangement of ectoplasmic specialization (ES) in testes, thus impairing spermiogenesis and spermiation. To understand the molecular mechanism, we found that expression of Odf2, a vital protein in spermatogenesis, was significantly decreased. In addition, we found that expression levels of Odf2 were decreased in Mkrn2 knockout mice. We also found that MKRN2 was prominently expressed in the sperm of normal men, but was significantly reduced in infertile men. This result indicates that our finding is clinically relevant. The results of our study provided insights into a new mechanism of male infertility caused by the MKRN2 downregulation

Increased aquaporin-1 levels in lens epithelial cells with primary angle-closure glaucoma

AIM: To determine the levels of aquaporin-1 (AQP-1) in the lens epithelial cells (LECs) of primary glaucoma and to clarify its correlation with lens thickness. METHODS: This study comprised 64 eyes of 64 patients with primary glaucoma, who were divided into 3 groups: 25 eyes of 25 patients with acute primary angle-closure glaucoma (APACG), 19 eyes of 19 patients with chronic primary angle-closure glaucoma (CPACG) and 20 eyes of 20 patients with primary open angle glaucoma (POAG). This study also included 12 eyes of 12 patients with senile cataract as controls. The levels of AQP-1 in LECs were examined by real-time quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry. The lens thickness was measured by A-scan ultrasonography. RESULTS: The AQP-1 mRNA levels of LECs were 0.84±0.27, 0.69±0.34, 0.44±0.19 and 0.51±0.21 in APACG, CPACG, POAG and senile cataract group, respectively. The levels of AQP-1m RNA were significantly higher in PACG groups compared with those in senile cataract and POAG group (all P<0.05). The immunohistochemistry showed the AQP-1 expression were strong-positive in PACG groups, but weak-positive in senile cataract and POAG group. A positive correlation was found between AQP-1 mRNA levels and the lens thickness (r=0.645, P<0.001). CONCLUSION: These findings show that the higher expression of AQP-1 in LECs may contribute to increased lens thickness, which might be associated with the occurrence and development of PACG